Pharmacokinetics
When given p.o., etamsylate is slowly
absorbed from the gastrointestinal tract. After oral administration
of 500 mg etamsylate maximum plasma level, i.e. 15 µg/ml,
is reached at 4 h, but bioavailability is not known. The
binding rate to plasma proteins is about 95%. Plasma half-life
is about 3.7 h.
About 72% of the administered dose are excreted in the
first 24 h-urine; the molecule is excreted unchanged.
After
i.v. administration of 500 mg etamsylate, the maximum
plasma level, i.e. 50 µg/ml, is reached after 10
minutes; plasma half-life is about 1.9 h. About 85% of
the administered dose are excreted in the first 24 h-urine.
Etamsylate crosses the placental barrier. Maternal and
cord blood contains similar concentrations of etamsylate.
It is not known if etamsylate is excreted in the maternal
milk.
Kinetics
in particular situations
It is not known if the pharmacokinetic properties of etamsylate
are modified in patients suffering from renal and/or hepatic
function disorders. |
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