Contraindications
Hypersensitivity towards the components of Doxiproct Plus®.

Precautions
In case of renal insufficiency, Doxiproct Plus® should not be used during long periods. Avoid long-lasting treatments.
In case of blood in the faeces or its suspected presence, as well as of a simultaneous occurrence of pain and fever, the physician must be consulted.
Treatment must be stopped in case of hypersensitivity reactions.

Pregnancy and lactation
Studies in pregnant women or animals are not available and it is not known whether calcium dobesilate crosses the placental barrier in humans. On the other hand, after topic administration, lidocaine hydrochloride and dexamethasone acetate are resorbed in variable quantities and can have systemic effects. Moreover, they cross the placental barrier. In these conditions, Doxiproct Plus® should be administered during pregnancy only if necessary.
After oral administration, calcium dobesilate is excreted into the maternal milk in low amounts, but it is not known whether this is the case with local use. After topic administration, lidocaine hydrochloride and dexamethasone acetate are excreted into the maternal milk. As a precaution, it should be decided between discontinuating the treatment or the breast-feeding.