Pharmacokinetics
After oral administration of 500
mg of calcium dobesilate, its blood level is above 6 µg/ml
between the 3rd and 10th hour, with a maximum (Cmax) of
8 µg/ml on the average after 6 hours (tmax). Twenty
four hours after intake blood level is about 3 µg/ml.
The rate of protein-binding is 20 - 25 %.
In animals, calcium dobesilate does not cross the haematoencephalic
or the placental barrier, but it is not known whether
this is also the case in humans. Calcium dobesilate enters
the maternal milk in very low quantities (0,4 µg/ml
after intake of 1500 mg as observed in one study).
Calcium dobesilate does not enter the enterohepatic cycle
and is excreted mainly unchanged with only 10 % being
excreted as metabolites.
About 50 % of the orally administered dose are eliminated
in the first 24-hour urine and about 50 % in the faeces.
Plasma half-life is around 5 hours.
Kinetics
in particular clinical situations
It is not known to what extent renal function disorders
influence the pharmacokinetic properties of calcium dobesilate
(see "Precautions"). |
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